Novel mechanism of antidepressant action: norepinephrine and dopamine disinhibition (NDDI) plus melatonergic agonism.
نویسنده
چکیده
All known antidepressants enhance monoamine neurotransmission, and most do so by blocking one or more of the reuptake transporters for serotonin, norepinephrine and/or dopamine (Stahl, 2000). Now comes agomelatine, a new agent that enhances norepinephrine and dopamine neurotransmission by a unique mechanism, namely 5-HT2C antagonism (Millan et al., 2003; Millan, 2005). Agomelatine is also a direct agonist at melatonin 1 (MT1) and MT2 receptors and a 5-HT2B antagonist (Millan et al., 2003).
منابع مشابه
Agomelatine improves symptoms of generalised anxiety disorder.
ED FROM Stein DJ, Ahokas AA, de Bodinat C. Efficacy of agomelatine in generalized anxiety disorder: A randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 2008;28:561– 6. Correspondence to: Dan J Stein, Department of Psychiatry, Groote Schuur Hospital, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa: [email protected] Source of funding: Se...
متن کاملElectroretinographic modifications induced by agomelatine: a novel avenue to the understanding of the claimed antidepressant effect of the drug?
BACKGROUND Agomelatine, the first melatonergic antidepressant, has been postulated to enhance the dopaminergic activity at the central nervous system by 5-hydroxytryptamine receptor type 2C (5-HT2C) antagonism, yet the impact of melatonergic agonism on this pathway is unclear. Previous studies employing simplified, yet reliable, proxy (retinal) measures of the central nervous system dopaminergi...
متن کاملMechanism of action of agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties.
ISSUE A striking and unexpected pharmacologic synergy has been shown between antagonist actions at serotonergic 5HT2C receptors, and agonist actions at melatonergic receptors by agomelatine, a drug that has both of these properties.
متن کاملAgomelatine beyond Borders: Current Evidences of Its Efficacy in Disorders Other than Major Depression
Agomelatine, a melatonergic antidepressant with a rapid onset of action, is one of the most recent drugs in the antidepressant category. Agomelatine's antidepressant actions are attributed to its sleep-promoting and chronobiotic actions mediated by MT1 and MT2 receptors present in the suprachiasmatic nucleus, as well as to its effects on the blockade of 5-HT2c receptors. Blockade of 5-HT2c rece...
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ورودعنوان ژورنال:
- The international journal of neuropsychopharmacology
دوره 10 5 شماره
صفحات -
تاریخ انتشار 2007